Lab co-directors

Eric Batard, MD, PhD, is Professor of Therapeutics in the Faculty of Medicine of the University of Nantes, and the Head of the Emergency Department of the Centre Hospitalier Universitaire de Nantes. He is the co-director of the MiHAR Lab. He gained his PhD thesis in 2005 on the relationship between the in vitro activity of antibiotics and their efficacy in animal models of infection. He started data mining when he used synchrotron radiation infrared and UV fluorescence microspectroscopy to study the diffusion of antibiotics in tissue bacterial communities. This experience allowed him to cosupervise for his PhD Emmanuel Montassier, who had to handle a great amount of data from gut microbiome. Then, he focused on the influence of antibiotic exposure on bacterial resistance. He intends to define antibacterial regimens that promote bacterial resistance as little as possible, especially in respiratory and urinary tract infections that he has to treat as an Emergency physician.

Didier Lepelletier, MD, PhD, is Professor of Bacteriology and Hygiene in the Faculty of Medicine of the University of Nantes, and the Head of the Bacteriology and Hygiene Department of the Centre Hospitalier Universitaire de Nantes. He is the co-director of the MiHAR Lab. From his PhD that he gained in 2006, he has been working on the influence of antibiotic exposure on bacterial resistance. As an hospital hygienist, he has to implement strategies to contain multidrug resistant (MDR) or highly resistant (HR) Enterobacteriaceae. However, these strategies are highly time and resource-consuming, and Didier intends to identify, among patients that have a MDR/HR organism carriage, those who are at risk of transmission to other patients, relatives or caregivers, and those who are at risk of infection. Taking account of the patients gut microbiome will help for that purpose.

Researchers

Pascale Bemer, MD, works as a Bacteriologist in the Bacteriology and Hygiene Department of the Centre Hospitalier Universitaire de Nantes. Pascale has an extensive experience in bacterial resistance, and she he is in charge of the preparation and quality control of fecal samples for Fecal Microbiota Transplantation in the Centre Hospitalier Universitaire de Nantes.

Gabriel Birgand, PharmD, PhD, works as an Hygienist in the Regional Centre for Pevention of Nosocomial Infections (ARLIN) at Nantes since 2015. In 2014,  he gained his PhD from the Pierre et Marie Curie University, Paris on the new tools for diagnosis and prevention of surgical site infections. He has published several studies on MDR/HR organism digestive carriage and infection control strategies.  He is currently a postdoc scholar in the NIHR Health Protection Research Unit in Healthcare Associated Infection and Antimicrobial Resistance at Imperial College London, where he obtained an Antimicrobial research collaborative early career research fellowship.

Céline Bourigault, PharmD, works as an Hygienist in the Bacteriology and Hygiene Department of the Centre Hospitalier Universitaire de Nantes, where she has dealt with various epidemics of Multidrug resistant organisms.

Eric Dailly, PharmD, PhD, is Professor of Pharmacology in the Faculty of Medicine of the University of Nantes, and the Head of the Clinical Pharmacology and Toxicology Laboratory of the Centre Hospitalier Universitaire de Nantes. He received his pharmacy and pharmacology (PhD) training at Paris V and Paris XII Universities. He works on factors affecting  in vivo drugs pharmacokinetics, including host factors (e.g. burn injury, obesity and drug interactions) and the intestinal microbiota.

Laure de Decker, MD, PhD, is a Geriatrician, Head of the Geriatric Acute Care Unit of the Centre Hospitalier Universitaire de Nantes. She gained her PhD in 2012 on the assessment of comorbidities in elderly patients. Due to frequent bacterial resistance, comorbidities and antibacterial therapies, elderly patients constitute a select population to study the interactions between host characterisics, antibiotics, digestive microbiota and bacterial resistance.
Emmanuel Montassier, MD, is Assisting Professor (Praticien Hospitalo-Universitaire) in the Faculty of Medicine of the University of Nantes, and works as an Emergency Physician in the Emergency Department of the Centre Hospitalier Universitaire de Nantes.  He gained his PhD in 2014 on the alterations of gut microbiota by myeloablative chemotherapy in non Hodgkin lymphoma patients. He received the Interscience Conference on Antimicrobial Agents and Chemotherapy Program Abstract Committee Award For Outstanding Abstract Presentation in the Area of Pathogenesis of Microbial Diseases in 2013. Then, Emmanuel specialized in bioinformatics and biostatistical analyses of microbiomes during a 1-year postdoctoral scholarship in Dan Knights Lab at the University of Minnesota Department of Computer Science and Engineering.

Gilles Potel, MD, PhD, is Professor of Therapeutics in the Faculty of Medicine of the University of Nantes, and the Director of the Federation of Anesthesiology, Intensive Care, Emergency Medicine, Internal Medicine and Infectious Diseases of the Centre Hospitalier Universitaire de Nantes. He was the former director of the Thérapeutiques cliniques et expérimentales des infections Lab, from which most of the MiHAR Lab members originated.  He has an extensive experience in animal models of infection, bacterial resistance and clinical use of antibacterial agents.


Jean-Ralph Zahar, MD, PhD, is Professor of Bacteriology and Hygiene in the Faculty of Medicine of the University of Angers, and Head of the Infection Control Unit of the Centre Hospitalier Universitaire d'Angers. He has extensively studied the digestive carriage of Multi-Drug  Resistant Organisms - especially Extended-Spectrum Beta-Lactamase producing Enterobacteriaceae - and Infection Control. He joined the MiHAR Lab to include the assessment of the digestive microbiota in Infection Control strategies.